Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Moderately Good
Based on 50 Reviews
7.9
Supplement Facts
Serving Size: 2 Vegetable Capsules
Amount Per Serving
%DV
Choline (as choline bitartrate)
500 mg
91%
Inositol
500 mg
**
Top Medical Research Studies
8
We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Read More
7
We aimed to explore the effects of myo-inositol (MI) supplementation on oxidative stress in obese patients suffering from non-alcoholic fatty liver disease (NAFLD). In our double-blinded, placebo-controlled study, 51 newly diagnosed patients were divided into two groups—one receiving 4 grams of MI daily and the other receiving a placebo—while following dietary recommendations for an 8-week period.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some ways—like a decrease in feelings of hunger and desire for unhealthy foods—the MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some ways—like a decrease in feelings of hunger and desire for unhealthy foods—the MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
Read More
Most Useful Reviews
9
Improved liver markers
102 people found this helpful
Excellent for liver support and alleviating anxiety. I researched choline as a supplement for NASH liver disease, finding that deficiencies in our diets may lead to fatty liver. Alongside my usual liver support (like milk thistle), my ALT liver enzyme normalised within months, and I found significant reductions in anxiety. This product is an excellent choice for liver health.
Read More
9
Liver support improvement
11 people found this helpful
At over 65, I suffer from fatty liver, and this choline seems to help. Since using it alongside inositol, I’ve noticed my mind feels sharper.
Read More
9
Cell regeneration
6 people found this helpful
Choline is crucial for restoring liver cells and preventing cardiovascular disease by reducing cholesterol. It promotes the regeneration of damaged liver cells and lessens gallstone formation. Lack of choline results in fat accumulation in the liver, leading to liver disease.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Read More
7
We aimed to explore the effects of myo-inositol (MI) supplementation on oxidative stress in obese patients suffering from non-alcoholic fatty liver disease (NAFLD). In our double-blinded, placebo-controlled study, 51 newly diagnosed patients were divided into two groups—one receiving 4 grams of MI daily and the other receiving a placebo—while following dietary recommendations for an 8-week period.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some ways—like a decrease in feelings of hunger and desire for unhealthy foods—the MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some ways—like a decrease in feelings of hunger and desire for unhealthy foods—the MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 50 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved liver markers
102 people found this helpful
Excellent for liver support and alleviating anxiety. I researched choline as a supplement for NASH liver disease, finding that deficiencies in our diets may lead to fatty liver. Alongside my usual liver support (like milk thistle), my ALT liver enzyme normalised within months, and I found significant reductions in anxiety. This product is an excellent choice for liver health.
Read More
9
Liver support improvement
11 people found this helpful
At over 65, I suffer from fatty liver, and this choline seems to help. Since using it alongside inositol, I’ve noticed my mind feels sharper.
Read More
9
Cell regeneration
6 people found this helpful
Choline is crucial for restoring liver cells and preventing cardiovascular disease by reducing cholesterol. It promotes the regeneration of damaged liver cells and lessens gallstone formation. Lack of choline results in fat accumulation in the liver, leading to liver disease.
Read More
9
Anxiety reduction
6 people found this helpful
I took 2 capsules a day and noticed a decrease in anxiety and panic attacks after two weeks. After a month, feelings of depression and apathy were significantly reduced. I trust Solgar; this product has been helpful.
Read More
9
Fat reduction
5 people found this helpful
Choline reduces blood cholesterol and fatty acids, cleaning blood vessel walls from cholesterol plaques. It aids in producing methionine, reducing homocysteine—a cardiovascular risk factor. Choline helps regenerate damaged liver cells and lowers gallstone formation, essential in preventing liver disease.
Read More
Frequently Asked Questions
9
Anxiety reduction
6 people found this helpful
I took 2 capsules a day and noticed a decrease in anxiety and panic attacks after two weeks. After a month, feelings of depression and apathy were significantly reduced. I trust Solgar; this product has been helpful.
7.5
Reduced anxiety
6 people found this helpful
I took two capsules a day for a month, and I noticed a significant reduction in my anxiety and panic attacks. My depression and apathy lessened markedly, and I felt a gentler effect overall. I also combined it with ginkgo biloba, which improved my clarity of thought. The choline in this product aids in restoring liver function. I trust Solgar, and this product has not disappointed me.
7.5
Fat metabolism support
14 people found this helpful
Choline stimulates the regeneration of liver cells damaged by drugs or viruses. A lack of choline leads to fat accumulation in the liver. I take 1 capsule twice daily for fatty hepatosis and have switched to this more concentrated version from Now Foods. Long-term use for 2-3 months is necessary.
7.5
Improved hematopoiesis
4 people found this helpful
My father, who has early liver disease and is on hemodialysis, has been taking one tablet daily for nearly six months. His recent blood tests show improved hematopoiesis. He plans to increase to two tablets daily.
9
Detox support
1 people found this helpful
It works wonders! I've struggled with liver problems for a while, and after taking it for detox, I immediately felt a sense of lightness in my body.
9
Hormonal balance
4 people found this helpful
Choline and inositol are essential for overall health, particularly for liver disease. I started taking this after my gynaecologist's recommendation, and within six months, my hormones normalised and my cycle improved. I believe this product achieved its purpose effectively.
9
Cleanses liver
Choline helps cleanse the liver, effectively assisting in treating liver disease.
9
Liver support improvement
11 people found this helpful
At over 65, I suffer from fatty liver, and this choline seems to help. Since using it alongside inositol, I’ve noticed my mind feels sharper.
9
Promotes liver detox
Great Inositol/Choline supports the nervous system, memory, and brain health. These substances aid in fat metabolism, liver protection, and toxin elimination. The quality is excellent.
7.5
Reduced anxiety
29 people found this helpful
Wonderful! Verified helps! I took 2 capsules a day and after 2 weeks, I noticed a reduction in my anxiety and panic attacks. After a month, my depression and apathy lessened significantly. The product acts gently without sudden shifts. I combined it with ginkgo biloba, noticing improved clarity of thought. The choline in this preparation aids in liver disease recovery. I trust Solgar and this product did not disappoint.
8
We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
7
We aimed to explore the effects of myo-inositol (MI) supplementation on oxidative stress in obese patients suffering from non-alcoholic fatty liver disease (NAFLD). In our double-blinded, placebo-controlled study, 51 newly diagnosed patients were divided into two groups—one receiving 4 grams of MI daily and the other receiving a placebo—while following dietary recommendations for an 8-week period.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some ways—like a decrease in feelings of hunger and desire for unhealthy foods—the MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some ways—like a decrease in feelings of hunger and desire for unhealthy foods—the MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
References
- Aghajani T, Arefhosseini S, Ebrahimi-Mameghani M, Safaralizadeh R. The effect of myo-inositol supplementation on AMPK/PI3K/AKT pathway and insulin resistance in patients with NAFLD. Food Sci Nutr. 2024;12:7177. doi:10.1002/fsn3.4267
- Rostami S, Arefhosseini S, Tutunchi H, Khoshbaten M, Ebrahimi-Mameghani M. Does myo-inositol supplementation influence oxidative stress biomarkers in patients with non-alcoholic fatty liver disease?. Food Sci Nutr. 2024;12:1279. doi:10.1002/fsn3.3842
